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新生儿大脑中的结构连接体的网络可控性.

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  • 1Department of Biomedical Engineering, Yale University, New Haven, CT, 06520, USA. huili.sun@yale.edu.

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大脑网络的可控性在第三个三个月出现,并迅速发展,支持认知功能. 过早出生会破坏这种发展,影响未来的认知能力.

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科学领域:

  • 神经科学是一个神经科学.
  • 发育神经科学的发展神经科学.
  • 网络科学 网络科学

背景情况:

  • 白质的连接性是通过限制大脑活动对认知功能至关重要的.
  • 网络可控性量化了大脑在精神状态之间过渡的能力.
  • 早期的大脑发育和早产对网络功能的影响尚未完全理解.

研究的目的:

  • 调查围产期网络可控性的发展轨迹.
  • 为了检查早产对婴儿大脑网络可控性的影响.
  • 探索早期网络可控性和以后的认知能力之间的关联.

主要方法:

  • 利用扩散MRI评估521名新生儿的白质连接性.
  • 从结构连接数据计算的网络可控性指标.
  • 与18个月龄的认知评估相关的出生控制能力.

主要成果:

  • 网络可控性的元素在妊娠的第三季度就已经存在,并且在分娩后迅速发展.
  • 过早出生显著改变了大脑网络的发展和状态转换所需的能量.
  • 出生时更高的网络可控性预测18个月后更好的认知结果.

结论:

  • 网络可控性是婴儿大脑快速发展的特性,对认知发展至关重要.
  • 过早分娩对大脑网络可控性的正常发展构成风险.
  • 早期的网络可控性可以作为预测认知轨迹的生物标志物.