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Updated: Jul 16, 2025

In-Nucleus Hi-C in Drosophila Cells
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染色体折叠和转录组中由凝聚素和相关因素引起的上下文依赖性扰动

Ryuichiro Nakato1, Toyonori Sakata2,3,4, Jiankang Wang5

  • 1Laboratory of Computational Genomics, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-Ku, Tokyo, 113-0032, Japan. rnakato@iqb.u-tokyo.ac.jp.

Nature communications
|September 19, 2023
PubMed
概括

凝聚蛋白通过染色体折叠影响基因表达. 新的计算工具分析了凝聚和相关因素如何影响3D基因组结构和基因活性,揭示了TAD分裂和表达变化之间的联系.

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