母亲和父亲的肥胖差异性重编程F1雌性大鼠的卵巢线粒体生物发生
Amina G Ramadan1, Wafaa M Abdel-Rehim2, Rasha A El-Tahan2
1Department of Biochemistry, Medical Research Institute, Alexandria University, 165 El-Horreya Avenue, EL-Hadara, POB: 21561, Alexandria, Egypt. amina.gaber@alexu.edu.eg.
Scientific reports
|September 19, 2023
概括
母亲和父亲的肥胖会对女性后代的卵巢健康产生负面影响,导致早期肥胖和生殖问题. 这些影响与改变的microRNA表达和线粒体功能障碍有关,这表明肥胖的跨代遗传.
科学领域:
- 生殖生物学 生殖生物学
- 内分泌学 在内分泌学.
- 遗传学 遗传学 是一个
背景情况:
- 肥胖对生殖健康构成重大风险.
- 表观遗传学和跨代效应越来越多地与肥胖传播有关.
- 了解父母肥胖对后代的影响对于生殖健康至关重要.
研究的目的:
- 研究母亲和/或父亲肥胖对第一代雌性老鼠后代卵巢组织的影响.
- 探索背后的分子机制代际肥胖传播.
主要方法:
- 在成年Wistar大鼠中诱导肥胖,使用肥胖性饮食三个月.
- 雌性老鼠与健康或肥胖的雄性交配,形成四个父母组:对照组,肥胖的父亲,肥胖的母亲和肥胖的父母.
- 从两个月大的雌性后代的卵巢组织和血液中分析了代谢,组织学和分子变化.
主要成果:
- 肥胖母亲 (OM或OP) 的后代表现出肥胖和代谢异常的早期迹象.
- 卵巢组织显示病变,毛囊生成受损,肥胖母亲后代的卵细胞质量下降.
- 观察到线粒体生物发生,氧化还原状态,炎症和microRNA (miR-149,miR-494) 表达的显著变化.
结论:
- 母亲和父亲的肥胖不同影响女性后代的卵巢健康.
- 卵巢微RNA表达的改变和线粒体生物生成途径的损害是肥胖的代际传播的关键因素.
- 这些发现突出了减轻肥胖的跨代生殖后果的潜在分子标.
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