社会和心理上的逆境与明显的母亲和婴儿肠道微生物组变异有关
Barbara B Warner1, Bruce A Rosa2, I Malick Ndao3
1Department of Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, MO, 63110, USA. warnerbb@wustl.edu.
Nature communications
|September 19, 2023
概括
怀孕期间的社会劣势和压力会改变母亲和婴儿的肠道微生物群. 这些与炎症相关的变化可能解释健康差异,并为干预提供目标.
科学领域:
- 微生物组研究的研究.
- 健康差异 在健康方面的差异.
- 发育生物学是发展生物学.
背景情况:
- 健康差异源于社会劣势和压力.
- 将产前不便与健康结果联系在一起的机制尚不清楚.
- 肠道微生物组和炎症是潜在的途径.
研究的目的:
- 在母婴二合体中研究肠道微生物组.
- 根据产前社会劣势和心理社会压力因素,比较微生物组的差异.
- 探索母亲细胞因子和婴儿肠道微生物组之间的联系.
主要方法:
- 未来的病例控制研究.
- 使用16S rRNA测序分析了121个母婴二的肠道微生物组.
- 枪支元基因组测序用于89个二.
- 评估了母亲循环中的细胞因子 (例如IL-6).
主要成果:
- 肠道微生物组特征预测了母亲和儿童的社会劣势和压力因素.
- 双杆菌物种和相关途径尤其受到影响.
- 高劣势/压力母亲表现出最低的肠道微生物组相似性.
- 4个月的婴儿肠道转基因组预测了母亲的产前IL-6水平.
结论:
- 产前社会和心理因素极大地影响了母亲和婴儿的肠道微生物组.
- 微生物组的改变,可能与炎症有关,可能会调解健康差异.
- 这些发现确定了减轻早期健康不平等的可修改目标.
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