塞法克洛尔在小鼠中引起迷走神经介导的类似抑郁症的症状与肠道失调症
Min-Kyung Joo1, Yoon-Jung Shin1, Dong-Hyun Kim2
1Neurobiota Research Center and Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Seoul, 02447, Korea.
Scientific reports
|September 19, 2023
概括
抗生素的使用,如,可以通过改变肠道细菌引发焦虑和抑郁. 向抗生素耐药细菌可能为这些疾病提供一种新的治疗方法.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗生素与神经心理效应,如焦虑和抑郁症有关.
- 血清激素路径的改变与焦虑和抑郁有关,通常与肠道疾病并发.
- 抗生素诱导这些作用的确切机制尚不清楚.
研究的目的:
- 为了研究如何塞法克隆,一个素抗生素,影响行为,肠道微生物群,和小鼠的大脑化学.
- 探索肠-大脑轴,迷走神经和血清素系统在抗生素诱导的神经精神疾病症状中的作用.
主要方法:
- 通过口服给小鼠注射塞法克洛,诱导焦虑和抑郁类行为和大肠炎.
- 对肠道微生物群组成,血清素水平和海马体5-HT受体mRNA表达的分析.
- 用vagotomy和fluoxetine进行干预,以评估它们对引起的症状和微生物变化的影响.
主要成果:
- 塞法克洛引发了焦虑和抑郁类行为,以及肠道失调的结肠炎.
- 塞法克降低了海马中的血清素水平,并改变了5-HT受体mRNA的表达.
- 吸血术部分缓解了行为症状,而素减少了行为和特定的抗生素耐药细菌.
结论:
- 塞法克洛引发的焦虑和抑郁症取决于肠道失调,涉及微生物群-肠道-大脑和微生物群-肠道-静脉神经-大脑通路.
- 向抗生素耐药细菌为抗生素相关的焦虑和抑郁症提供了潜在的治疗策略.
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