最近的自然选择通过非对抗性的类向性来保护精神分裂症
Javier González-Peñas1,2,3, Lucía de Hoyos4,5,6, Covadonga M Díaz-Caneja4,5,7,8
1Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Calle Ibiza, 43, 28009, Madrid, Spain. javier.gonzalez@iisgm.com.
Scientific reports
|September 19, 2023
概括
由于最近的自然选择 (RNS) 作用于保护性特征而不是大脑功能,精神分裂症风险等位基因仍然存在. 这表明非对抗性类型解释了精神分裂症倾向的进化悖论.
科学领域:
- 进化生物学是进化的生物学.
- 精神病学遗传学 精神病学遗传学
- 人口遗传学 人口遗传学
背景情况:
- 精神分裂症呈现出一种进化悖论,由于尽管有显著的遗传贡献,但生育能力和寿命减少.
- 以前像平衡选择这样的解释越来越多地受到证据的挑战,这些证据反对风险等位基因的积极选择.
- 随着人类环境的变化,对精神分裂症风险等位基因的进化压力可能发生了变化.
研究的目的:
- 为了研究精神分裂症倾向位置和最近的自然选择 (RNS) 签名之间的关系.
- 探索RNS在人类从非洲迁移后精神分裂症相关遗传变异的持续性中的作用.
主要方法:
- 1000个基因组项目数据的全基因组分析.
- 最近自然选择 (RNS) 标记物的识别和分析.
- 分区遗传性和基因组丰富分析对精神分裂症易感基因的分析.
主要成果:
- 在提供对精神分裂症保护的衍生基因中发现了RNS标记物的显著丰富.
- 在RNS下与精神分裂症风险局部相关的基因显示,与非RNS相比,大脑和神经元功能的参与减少.
- 有证据表明,RNS与非精神病学表型有关.
结论:
- 最近的自然选择 (RNS) 可能解释了精神分裂症倾向变异的持久性.
- 非对抗性性质被认为是潜在的机制,其中RNS影响保护性非精神病特征.
- 这解决了精神分裂症常见遗传变异的进化悖论.
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