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Optimization of the Wound Scratch Assay to Detect Changes in Murine Mesenchymal Stromal Cell Migration After Damage by Soluble Cigarette Smoke Extract
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一个多式传感环用于量化痕强度.

Akhil Padmanabha1, Sonal Choudhary2, Carmel Majidi3,4

  • 1Robotics Institute, Carnegie Mellon University, Forbes Avenue, Pittsburgh, 15213, PA, USA. akhilpad@andrew.cmu.edu.

Communications medicine
|September 19, 2023
PubMed
概括
此摘要是机器生成的。

这项研究介绍了一种可穿戴设备,可以客观地测量慢性的强度,超越了简单的痕检测. 这项创新量化了的强度,以改善患者护理和相关疾病的研究.

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科学领域:

  • 生物医学工程 生物医学工程
  • 可穿戴技术可穿戴技术
  • 数据科学数据科学数据科学

背景情况:

  • 对慢性的客观测量对于管理各种疾病至关重要.
  • 目前的可穿戴设备可以检测痕,但不能检测其强度,从而限制了患者的护理.
  • 了解的强度是评估它对个人的影响的关键.

研究的目的:

  • 开发一个框架来估计使用多式联用可穿戴设备的划痕强度.
  • 为了实现对行为客观的实时量化.
  • 改善患者护理和慢性的研究.

主要方法:

  • 开发了一种多式环装置,配有加速度计和接触式麦克风.
  • 一个压力敏感的平板电脑被用来捕捉地面真相的强度.
  • 机器学习算法用于划痕强度回归 (0-600mW尺度).

主要成果:

  • 该框架成功地通过临床相关的歧视来估计伤强度.
  • 在20个个体中使用了leave-one-subject-out交叉验证.
  • 来自另外14名参与者的数据验证了算法的性能.

结论:

  • 一个戴在手指上的设备可以提供多维的,客观的,实时测量痕.
  • 这项技术允许量化痕强度变化的量化.
  • 这些发现支持改善了对的严重程度的临床评估.