末潮部分压力的负对数变化表明了健康的日本受试者中电极电位的变化
Teruo Kiyama1,2,3, Akira Tokunaga4, Abumrad Naji5
1Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Nippon Medical School, Bunkyo, Tokyo, Japan. kiyama@nms.ac.jp.
Scientific reports
|September 19, 2023
概括
潮尾呼吸分析显示,分子 (H2) 水平在一天中发生变化. 呼出H2的这些变化,以pH2计量,反映了健康个体体体内的电极潜力的变化.
科学领域:
- 生物医学工程 生物医学工程
- 呼吸系统生理学 呼吸系统生理学
- 分析化学 分析化学
背景情况:
- 分子 (H2) 是人类结肠微生物组活动的副产品,并被呼出.
- 潮尾H2采样提供了一种非侵入性方法来评估膜H2.
- 纳恩斯特方程将离子比率与电极电位联系起来,以pH为一个熟悉的例子.
研究的目的:
- 调查pH2的变化 (有效H2压力的负对数) 是否与电极电位变化相关.
- 为了确定潮尾pH2是否可以使用便携式呼吸传感器进行非侵入性测量.
- 在健康个体中评估潮末 pH2 的每日波动.
主要方法:
- 在酸盐缓冲溶液中实验验证pH2-电极潜在关系.
- 用手持式传感器测量149名日本健康受试者的潮末H2.
- 在基线 (早晨) 和活动后 (中午) 进行的潮末H2测量结果的比较.
主要成果:
- 发现电极电位的变化与缓冲溶液中的 ([公式:参见文本]) 相称.
- 平均基线潮结束时的pH2为4.89,每日活动后增加0.15.
- 这种pH2的变化与电极电位中大约4.6mV的氧化相对应.
结论:
- 潮末的pH2测量有效地表明了日常活动期间电极电位的变化.
- 便携式呼吸H2传感器可以可靠地跟踪这些生理变化.
- 这种非侵入性方法为监测内部氧化还原状态提供了一种新的方法.
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