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Updated: Jul 16, 2025

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
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Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses

Published on: May 6, 2019

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人类和小鼠的相对CD4和CD8T细胞免疫主导:对临床前测试的影响

Tertuliano Alves Pereira Neto1, John Sidney1, Alba Grifoni2

  • 1Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA, 92037, USA.

Cellular & molecular immunology
|September 19, 2023
PubMed
概括

这项研究表明,虽然小鼠模型显示T细胞对SARS-CoV-2抗原反应的相关性较弱,但使用人类白细胞抗原转基因小鼠显著提高了疫苗开发的预测准确性. 这些发现为临床前测试提供了指导.

关键词:
对动物进行试验.哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈这就是SARS-CoV-2病毒.在T细胞,T细胞.疫苗 疫苗 疫苗 疫苗

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