相关实验视频
Updated: Jul 16, 2025

13:25
Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish
Published on: May 15, 2021
5.8K
儿童癌症后的长期西斯甲毒性:系统性审查和元分析
Jessica Schofield1, Matthew Harcus2, Barry Pizer2
1Department of Women's and Children's Health, University of Liverpool, Liverpool, UK.
Pediatric nephrology (Berlin, Germany)
|September 19, 2023
概括
儿童癌症的长期西斯治疗经常导致脏损伤,大约三分之一的患者经历了减少的膜过率 (GFR) 或低磁血. 较高的累积西斯丁剂量增加了这种风险.
科学领域:
- 儿科瘤学 儿科瘤学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 临床药理学 临床药理学
背景情况:
- 西斯普拉丁是儿童固体瘤的基石化疗,但与长期损伤 (毒性) 有关.
- 常见的表现包括减少质过率 (GFR) 和低磁血,在现有文献中报告的患病率和危险因素具有显著的变化.
结论:
- 长期毒性,特别是降低GFR和低磁性血,影响了大约三分之一的儿童癌症幸存者接受了西斯.
- 研究方法差异很大,阻碍了最终的分析,并强调了对标准化评估的需求.
- 需要进一步的研究来阐明降低GFR和低磁性血的关系,确定额外的危险因素,并了解个人对西斯产生的毒性敏感性.
相关概念视频
Kidney Transplant II: Surgical Procedure
36
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
36
Acute Kidney Injury III: Clinical Manifestations
29
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
29
Acute Kidney Injury IV: Diagnostic Studies and Prevention
34
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
34
Kidney Transplant III: Nursing Management
39
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
39
Kidney Transplant I: Introduction
28
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
28
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
190
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy. SP binds and activates...
190

