睡眠障碍和肺癌风险:一个超流行病学研究
Tong Zhou1,2, Zichen Wang1, Chenxi Qiao1
1Department of Oncology, China Academy of Chinese Medical Sciences Guang'anmen Hospital, Beixian'ge Street No. 5 Xicheng District, Beijing, China.
BMC cancer
|September 19, 2023
概括
睡眠障碍,如睡眠短暂,长时间睡眠和失眠,与患肺癌的风险更高有关. 这些发现强调了解决睡眠问题的重要性,以预防肺癌.
科学领域:
- 肺部医学 肺部医学
- 睡眠科学 睡眠科学
- 流行病学 流行病学
背景情况:
- 睡眠障碍与肺癌之间的联系复杂且双向.
- 睡眠障碍越来越被认为是影响癌症风险的潜在因素.
- 这项研究调查了各种睡眠模式与肺癌发病率之间的联系.
研究的目的:
- 探索睡眠障碍与肺癌风险之间的潜在关联.
- 对睡眠障碍和肺癌的现有证据进行系统审查和元分析.
- 为了确定与增加肺癌风险相关的特定睡眠模式.
主要方法:
- 在主要数据库 (PubMed,Embase,Cochrane图书馆,Web of Science) 进行了全面的文献搜索.
- 对几率比率 (ORs) 和95%置信区间 (CI) 的元分析使用Stata 17.0.0进行.
- 研究质量使用纽卡斯尔-太华尺度进行评估,出版偏差使用漏斗图和埃格尔回归测试进行评估.
主要成果:
- 包括11项涉及469,691名参与者的研究.
- 睡眠时间短 (<7-8小时) 增加了13%的肺癌风险 (OR:1.13).
- 长时间的睡眠时间 (>7-8小时),失眠症状和晚间时间型也与更高的肺癌风险有显著联系.
结论:
- 睡眠障碍,包括睡眠不足/过度,失眠和晚间时间型,是增加肺癌风险的重要预测因素.
- 研究结果表明,睡眠障碍应该被视为肺癌易感性的独立风险因素.
- 需要进一步的研究来阐明机制,如黑激素分泌和免疫-炎症平衡,并探索调解因素,如年龄和职业.
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