在食道中Lugol-unstained病变的位置会影响恶性瘤的检测率:一个基于人口的研究
Jing Qin1, Mengfei Liu1, Anxiang Liu2
1State Key Laboratory of Molecular Oncology, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Genetics, Peking University Cancer Hospital & Institute, Beijing, China.
Journal of gastroenterology and hepatology
|September 20, 2023
概括
上部和中部食道的Lugol-unstained病变 (LUL) 具有较高的检测率,可检测重度形及以上 (SDA). 内镜医生应优先考虑这些位置,特别是在患有食道状细胞癌 (ESCC) 家族病史的患者中.
科学领域:
- 胃肠病学 胃肠病学
- 内镜检查是指内镜检查.
- 在瘤学瘤学.
背景情况:
- 卢戈尔未染色的病变 (LULs) 是内镜检查期间活检的指标.
- 了解LUL位置对检测产量的影响对于有针对性的活检至关重要.
研究的目的:
- 评估Lugol未染色病变 (LULs) 的位置如何影响严重发育不良及以上发育不良 (SDA) 的检测率.
- 引导内镜医生选择最佳的活检点,以提高诊断产量.
主要方法:
- 在一项基于人群的试验中,分析了1166个Lugol未染色病变 (LULs),记录了1064名受试者的位置和病理.
- 基于活检结果计算SDA检测率.
- 后勤回归与一般化的估计方程来评估LUL位置和SDA风险之间的关联.
主要成果:
- 严重形及以上 (SDA) 的检测率从低食道的5.9%增加到中食道的10.9%和上食道的16.7%.
- 低位与SDA检测有显著的关联 (OR上方与下方 = 2.88;OR中方与下方 = 1.63).
- 这种关联在患有食道状细胞癌 (ESCC) 的家族史的人群中显著更强烈.
结论:
- 上部和中部食道的Lugol-unstained病变 (LULs) 需要在内镜检查期间更加注意.
- 内镜医生应优先考虑这些上部区域的LUL活检,特别是对于患有食道状细胞癌 (ESCC) 家族病史的患者.
- 这种有针对性的方法可以提高癌前病变的检测.
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