在COVID-19的预后中的新型炎症生物标志物
Kegang Zhan1,2, Luhan Wang1, Hao Lin3
1Department of Epidemiology, College of Preventive Medicine, Third Military Medical University (Army Medical University), Chongqing, China.
新型炎症生物标志物如内分泌和MDW在COVID-19患者中升高,可以预测不良预后和死亡. 这些发现有助于理解COVID-19的进展和患者的结果.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 生物标志物发现发现
背景情况:
- 炎症进展是COVID-19严重程度的核心.
- 新型炎症生物标志物在COVID-19中的预后作用受到争论.
研究的目的:
- 评估特定的新型炎症生物标志物对COVID-19发生和预后的影响.
- 综合当前关于COVID-19患者管理中的生物标志物实用性的证据.
主要方法:
- 90项涉及12059名参与者的研究的系统检索.
- 使用标准化平均差异进行元分析,以比较群体之间的生物标志物水平.
- 对精选的炎症生物标志物的数据进行分类和汇集.
主要成果:
- 在COVID-19阳性个体中,内分泌,PTX3,suPAR,sRAGE,galectin-3和MDW的水平升高.
- 高水平的PTX3,sCD14-ST,suPAR和MDW与死亡率相关.
- 恩多坎,加勒-3,sCD14-ST,suPAR和MDW与较差的临床预后有关.
结论:
- 这一元分析提供了关于COVID-19预后新型炎症生物标志物的全面证据.
- 生物标志物在预测死亡和不良结果方面表现出显著的歧视能力.
- 研究结果支持使用这些生物标志物来加强COVID-19患者的评估.
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