全球模式和相关性在人类抗菌素耐药性的出现
Emma Mendelsohn1, Noam Ross1, Carlos Zambrana-Torrelio1
1EcoHealth Alliance, 520 Eighth Avenue, Ste. 1200, New York, NY 1018, USA.
Proceedings. Biological sciences
|September 20, 2023
概括
人类出现抗菌素耐药性 (AMR) 与抗生素使用有关. 人类的旅行也促进了全球耐药细菌的传播,突出显示了监测差距.
科学领域:
- 全球健康 全球健康
- 微生物学 微生物学
- 流行病学 流行病学
背景情况:
- 抗菌素耐药性 (AMR) 是一个重大的全球卫生挑战.
- 了解新型抗生素耐药细菌在人类中出现的驱动因素至关重要,但在全球范围内研究不足.
- 关于抗菌素耐药性驱动因素的现有研究,特别是关于畜牧业抗生素使用的研究,需要进一步调查.
研究的目的:
- 调查人类抗菌素耐药性出现的全球相关性.
- 分析人类和牲畜抗生素消费,经济活动和AMR出现之间的关系.
- 确定人类旅行在全球传播和新型AMR菌株检测中的作用.
主要方法:
- 利用2006-2017年关于新型AMR细菌菌株起源的全球数据.
- 检查了与人类和牲畜抗生素使用的相关性,以及国家一级的国内生产总值 (GDP).
- 将报告偏差指标和人类旅行数据纳入分析.
主要成果:
- 人类中AMR的出现显示出与人类抗生素消费的积极相关性.
- 畜牧业抗生素使用与抗菌素耐药性出现之间的关联被GDP所缓和,仅在GDP较高的国家有轻微的积极联系.
- 人类旅行被确定为新型AMR菌株出现和随后检测的潜在因素.
结论:
- 人类消费抗生素是AMR出现的关键驱动力.
- 牲畜抗生素使用对抗菌素耐药性出现的影响是复杂的,受经济因素的影响.
- 人类旅行促进了AMR的全球传播,强调需要加强全球监测和有针对性的干预措施来缓解AMR的传播.
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