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验证的HPLC-UV方法,用于在接受AmBisome并接受体外替代疗法治疗的危急患者中量化AMPHOTERICIN B

Carlos Ezquer-Garin1,2, Gerardo Aguilar1,3, Rafael Ferriols-Lisart1,2

  • 1INCLIVA, Valencia, Spain.

Biomedical chromatography : BMC
|September 20, 2023
PubMed
概括

一种新的HPLC-UV方法准确地测量了血中的安福特里辛B (AMB),有助于对AmBisome和体外疗法的危急患者进行药理学研究.

关键词:
阿姆比索姆 (AmBisome) 是一种在HPLC-UV中使用.氨基氨酸 B 是一种氨基氨酸.开发方法开发方法的方法.药物动力学 药物动力学验证验证的时间

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Antifungal Agents01:15

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Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...