在缺乏区域的贝塞斯达类IV甲状腺结核中存在恶性瘤风险
Tommaso Loderer1, Elena Bonati1, Valentina Donato1
1Department of Medicine and Surgery, General Surgery Unit, Parma University Hospital, Parma, Italy.
Gland surgery
|September 20, 2023
概括
对贝塞斯达IV甲状腺结节进行诊断性叶切除术是最好的,符合指南. 由于恶性瘤和侵袭风险较高,建议在大型结节 (≥4厘米) 时进行全甲状腺切除术.
科学领域:
- 内分泌学 在内分泌学.
- 手术瘤学手术瘤学
- 甲状腺病理 甲状腺病理
背景情况:
- 目前的指导方针建议对具有不确定的细胞学的高风险甲状腺结节进行诊断性叶切除术,除非存在特定因素,否则应避免全甲状腺切除术.
- 贝塞斯达类IV结核占甲状腺病态中需要手术干预的很大一部分.
研究的目的:
- 评估贝塞斯达类IV甲状腺结节在缺地区的手术方法.
- 分析癌瘤发病率,结节特征和与外科手术策略相关的治疗结果.
主要方法:
- 对320名接受贝塞斯达IV结节手术的患者进行了回顾性观察性研究 (2010-2020年).
- 分析手术前的结节大小,组织学发现,手术方法 (小肠切除术与全甲状腺切除术) 以及放射代谢治疗的需要.
主要成果:
- 在2015年ATA指导方针之后,人们观察到一种转向保守的外科手术方法的转变,叶叶切除术从7.2%增加到41.5%.
- 贝塞斯达IV结节的总体恶性瘤率为28.8%.
- 与较高的恶性瘤率 (P<0.01),较高的局部/淋巴血管入侵率 (P<0.05) 和较大的卵泡癌相比,卵泡癌与较高的恶性瘤率相关 (P<0.001).
结论:
- 诊断性叶切除术是贝塞斯达IV甲状腺结节的首选初始手术方法,除非存在全甲状腺切除术的禁忌.
- 建议对大结节 (≥4厘米) 进行全甲状腺切除术,因为它们与更高的恶性瘤发病率,入侵和 postoperative radiometabolic 治疗的需要有关.
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