唾液血管内皮细胞生长因子和表皮细胞生长因子水平在患有复发性口腔口炎的患者:一个元分析
Paria Motahari1, Davood Fathollahzadeh2, Amir Alipour3
1Dept. of Oral and Maxillofacial Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
Journal of dentistry (Shiraz, Iran)
|September 20, 2023
概括
唾液表皮生长因子 (EGF) 和血管内皮生长因子 (VEGF) 在患有复发性口腔口炎 (RAS) 的患者中显著降低. 这一发现表明,它们降低的水平在RAS发育中起作用.
科学领域:
- 口腔医学是指口腔医学.
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
背景情况:
- 复发性口腔口腔炎 (RAS) 是一种普遍存在的口腔疾病,其病因不明.
- 表皮生长因子 (EGF) 和血管内皮生长因子 (VEGF) 都与RAS有关,但研究结果不一致.
研究的目的:
- 进行一项元分析,评估RAS患者的唾液EGF和VEGF水平.
- 为了确定唾液EGF/VEGF和RAS活动或缓解之间的关联.
主要方法:
- 在多个数据库 (Web of Science,PubMed,Embase,Scopus等) 中进行系统的文献搜索. 截至 2022 年 1 月.
- 包括评估RAS患者唾液EGF和VEGF的病例控制研究.
- 使用全面的元分析软件进行统计分析,通过Cochrane Q和I2测试评估异质性.
主要成果:
- 七项研究被纳入了元分析.
- 唾液EGF和VEGF水平在RAS的活性和缓解阶段与健康个体相比显著较低 (p<0.05).
- 与愈合阶段相比,这些唾液因子在RAS活跃阶段也明显较低.
结论:
- 降低EGF和VEGF的唾液水平与复发性口腔口炎有显著的相关性.
- 这些发现凸显了EGF和VEGF在RAS病变发生过程中的潜在作用.
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