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肝炎E病毒查在英国的影响已故器官捐献者人口

Ines Ushiro-Lumb^1,2,3, John Forsythe¹, Becky Haywood²

¹Organ and Tissue Donation and Transplantation, NHS Blood and Transplant, London, United Kingdom.

Transplant international : official journal of the European Society for Organ Transplantation

|September 20, 2023

概括

对器官捐献者的普遍肝炎E病毒 (HEV) 查有助于在移植后检测感染. 这一策略允许早期管理,以防止通过器官移植传播的HEV导致的肝损伤.

科学领域:

* 移植免疫学移植免疫学
* 病毒学病毒学
* * 公众健康

背景情况:

* 已故器官捐献者的普遍肝炎E病毒 (HEV) 查在2017年10月在英国实施.
*捐赠者检测发生在移植后,HEV RNA检测通知接受者管理,而不是违反捐赠.
*移植后立即检测出供体HEV病毒病,引发了移植中心的通知.

研究的目的:

* 评估在已故器官捐献者中普遍HEV查的有效性.
*通过实体器官移植来评估HEV传播率.
* 为了告知接受者管理和预防慢性HEV感染导致的加速肝损伤.

主要方法:

*对已故器官捐献者实施普遍的HEV查.
*移植后对肝脏和脏接受者进行HEV感染的监测.
* 供体HEV病毒载荷与受体传播事件的相关性.

主要成果:

*通过固体器官,特别是肝移植,通过HEV的传播被发现是非常有效的.
* 供体HEV病毒性与受体感染有关,即使在较低的病毒载荷 (VL) 中.
* 了解供体HEV状态有助于识别传播和明智的临床决策.

结论:

*对器官捐献者进行普遍的HEV查对于识别传播风险至关重要.
*在接受者中早期发现和治疗HEV感染可以预防严重的肝损伤.
*该策略允许对患有HEV传播风险的患者进行知情的临床管理和监测.

关键词:

进行捐赠者查.从供体获得的感染.源自供体的传播来源于供体.乙型肝炎病毒的感染.与移植相关的感染.

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