在使用吸入性皮质类固醇的免疫能力较强的喘患者中发现密码球菌喉炎
G I Butel-Simoes1, H Kua2, A Safdar3
1Monash Infectious Diseases and Microbiology, Monash Health, Victoria, Australia.
Medical mycology case reports
|September 20, 2023
概括
本案例研究突出了喉密码球菌病,这是由Cryptococcus neoformans var.引起的真菌感染. 格鲁比,在一个滥用吸入性皮质类固醇的患者. 及时诊断和六个月的弗卢可纳治疗使她完全康复.
科学领域:
- 菌类学 菌类学是指菌类学.
- 传染性疾病 传染性疾病
- 肺部病理学 肺部病理学
背景情况:
- 使用高剂量的皮质类固醇,特别是吸入性皮质类固醇,可以使个人易患机会性真菌感染.
- 加密球菌病是一种机会性真菌感染,通常是由Cryptococcus neoformans或Cryptococcus gattii引起的.
研究的目的:
- 在过度吸入皮质类固醇使用的患者中报告喉密码球菌病例.
- 强调在长期接受类固醇治疗的患者中考虑非Candida真菌感染的重要性.
- 突出加密菌喉炎的诊断和治疗方法.
主要方法:
- 一名患者出现了长期症状和喉质量损伤.
- 通过鼻镜检查,组织病理学和活检的微生物学评估来确认诊断.
- 治疗涉及六个月的流可纳疗程.
主要成果:
- 由Cryptococcus neoformans var.引起的喉性加密球菌病. 格鲁比被诊断出了这种病.
- 患者在6个月的弗卢科纳治疗后实现了临床治愈和症状消失.
- 这一案例强调了在高剂量吸入性皮质类固醇患者中严重真菌感染的可能性.
结论:
- 喉密码球菌病是一种罕见但可治疗的机会性感染,患者使用过多的吸入性皮质类固醇.
- 通过活检进行早期诊断,并及时使用像弗卢科纳这样的抗真菌剂进行治疗,对于成功的结果至关重要.
- 临床医生应在长期接受类固醇治疗的患者中保持对非Candida真菌感染的高度怀疑指数,特别是在当前的医疗环境中.
更多相关视频
10:39Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
Published on: April 16, 2019
7.7K
07:28Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
Published on: April 6, 2017
40.7K
相关概念视频
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
295
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
295
01:26COPD: Management Using Bronchodilators and Corticosteroids
241
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
241
01:20Asthma: Pathogenesis and Management
439
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
439
01:30Asthma-IV: Diagnostic and Management
2.5K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.5K
01:23Inhaled Medications
305
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
305
01:24Asthma-III: Symptoms and Complications
2.5K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Classification of Asthma
2.5K