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接种Covid-19疫苗和慢性疹:一个范式研究
Anubha Dev1, Apoorva Sharma1, Anuradha Bishnoi1
1Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Indian dermatology online journal
|September 20, 2023
概括
COVID-19疫苗可以引发慢性疹 (CU),导致疫苗诱导的疹 (VIU) 或疫苗加剧的疹 (VEU). 在大多数患者接种疫苗后,标准抗胰岛素治疗有效控制了CU症状.
科学领域:
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
- 疫苗学 疫苗学 疫苗学
背景情况:
- COVID-19大流行刺激了疫苗的快速开发,对其对慢性疹 (CU) 影响的研究有限.
- 了解COVID-19疫苗接种和CU之间的关系对于患者管理和疫苗信心至关重要.
研究的目的:
- 为了研究COVID-19疫苗接种对慢性疹患者队列的影响.
- 与疫苗接种有关的病事件的分类和治疗结果的评估.
主要方法:
- 来自疹病诊所的病例记录的回顾性分析 (2021-2022年3月).
- 根据与疫苗接种相关的症状发作,将患者分为疫苗诱发性疹 (VIU) 或疫苗恶化性疹 (VEU).
- 维生素D3水平的比较和疫苗接种问题与疹活动评分 (UAS-7) 的相关性分析.
主要成果:
- 在265名接种了CU疫苗的患者中,12名患有VEU (10名接种了腺病毒载体疫苗) 和3名患有VIU (所有接种了非活化病毒疫苗).
- 与非恶化的CU患者相比,VEU患者的维生素D3水平较高 (p=0.003).
- 关于不良影响的担忧和疹活动得分之间存在显著的相关性 (Pearson r=0.66,P=0.007).
结论:
- 接种COVID-19疫苗可以加速或恶化慢性疹.
- 在接种疫苗后的大多数患者中,标准抗组胺药物治疗有效地控制了疹症状.
- 需要进一步的研究来阐明机制和长期影响.
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