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在帕金森病中的瞳孔光反射动态

Panagiota Tsitsi^1,2, Mattias Nilsson³, Josefine Waldthaler^1,2

¹Department of Clinical Neuroscience, Neuro, Karolinska Institutet, Stockholm, Sweden.

Frontiers in integrative neuroscience

|September 20, 2023

概括

在帕金森病 (PD) 患者中,瞳孔光反射 (PLR) 较慢,特别是那些像正静性低血压 (OH) 等自主功能障碍患者. 这项眼睛追踪研究突出了PLR缺陷和PD中的dysautonomia之间的潜在联系.

科学领域:

神经科学是一个神经科学.
眼科医生眼科眼科
自主神经系统研究自主神经系统研究

背景情况:

视觉障碍在帕金森病 (PD) 中很常见.
缺陷的瞳孔光反射 (PLR) 被怀疑是导致PD视觉问题的原因之一.
自主功能障碍 (dysautonomia) 是PD中常见的非运动性症状,但其与PLR的联系尚未研究.

研究的目的:

为了比较健康对照 (HC),PD患者没有dysautonomia和PD患者与dysautonomia之间的PLR参数.
使用眼睛追踪技术调查PLR和PD中自主功能障碍之间的关联.

主要方法:

招募了43名HC和50名PD患者.
使用Tobii Pro Spectrum测量PLR,使用短 (100毫秒) 和长 (1000毫秒) 的光刺激.
使用静止性低血压 (OH) 作为dysautonomia的代理;用线性混合效应模型和非参数统计数据分析数据.

主要成果:

与HC相比,PD患者的峰值PLR收缩速度较慢,PD患者的高血压患者的差异更明显.
扩张幅度和速度显示从HC逐渐减少到PD没有OH到PD与OH.
在混合模型中,年龄是扩张反应的重要预测因素.

结论:

这些发现支持以前的研究表明PD中存在缺陷PLR,通过眼睛跟踪进行评估.
结果表明,在帕金森病中,受损的PLR和自主功能障碍之间存在潜在的关联.
建议对更大的队列进行进一步的研究和全面的自主功能评估,以证实这些发现.

关键词:

帕金森病是帕金森氏症的一种疾病.两种自主性两个自主性眼睛的运动眼睛的运动眼睛跟踪眼睛跟踪学生的反射反应

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