间歇性禁食和临床风险评分的变化:随机对照试验的二次分析
Benjamin D Horne1,2, Jeffrey L Anderson1,3, Heidi T May1
1Intermountain Medical Center Heart Institute, Salt Lake City, UT, USA.
间歇性禁食可能会增加寿命,但会增加短期死亡风险. 这项研究发现,禁食降低了慢性疾病风险得分 (PCRE,ICHRON) 并改善了HOMA-IR,特别是在基线风险较高的人群中.
科学领域:
- 代谢健康 代谢健康
- 评估心血管风险评估
- 长寿研究研究 长寿研究
背景情况:
- 间歇性禁食 (IF) 与长寿和心脏代谢风险降低的潜在益处有关.
- 临床风险评分用于预测死亡率和慢性疾病的发展.
- 对IF对已确定的临床风险得分的影响需要进一步调查.
研究的目的:
- 评估26周间歇性禁食对临床死亡率和慢性疾病风险评分的影响.
- 评估山间死亡风险评分 (IMRS),聚合队列风险方程 (PCRE) 和山间慢性疾病评分 (ICHRON) 的变化.
- 检查HOMA-IR和代谢综合征得分 (MSS) 与基线风险水平相关的修改.
主要方法:
- 一项随机对照试验,涉及71名21至70岁的参与者,具有代谢综合征标准.
- 间歇性禁食组:24小时纯水禁食,每周禁食两次,持续4周,然后每周禁食一次,持续22周.
- 控制组:适合自己的饮食. 在26周分析了IMRS,PCRE,ICHRON,HOMA-IR和MSS的变化.
主要成果:
- 间歇性禁食显著增加了山间死亡风险评分 (IMRS) (0.78对 -0.61,p=0.010).
- IF降低了山间慢性疾病得分 (ICHRON) (-0.92比0.58,p=0.035) 并倾向于降低PCRE (-0.20比-0.14,p=0.054).
- IF在基线IMRS较高的个体中显示出HOMA-IR的较大降低,这表明风险分层效应.
结论:
- 间歇性禁食似乎增加了短期死亡风险 (IMRS),同时降低了长期慢性疾病风险 (PCRE, ICHRON).
- 观察到的IMRS增加可能会作为长期健康益处的生理触发剂.
- 禁食干预措施可能需要仔细考虑短期安全性,特别是在基线风险概况较高的个体中.
更多相关视频
06:13Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health
Published on: December 1, 2023
08:13Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
Published on: January 7, 2018
相关概念视频
Metabolic States of the Body: Fasting and Starvation
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
