在患有初级高血压的患者中,前血栓性状态的相关检测指标
Jie Luo1, Tuo Yang2, Lan Ding3
1Medical Technology Department, Jiangxi Medical College, Shangrao 334000, Jiangxi Province, China.
World journal of clinical cases
|September 20, 2023
概括
像hs-CRP和FIB这样的血栓前状态指标在初级高血压 (PH) 患者中不同. 这些标记物的异常水平,包括TM,Hct,ESR,CD62P,PLT,APTT,PT和TT,是PH进展和血栓形成风险的关键.
科学领域:
- 心血管医学 心血管医学
- 临床病理学 临床病理学
- 血液学 血液学 血液学
背景情况:
- 初级高血压 (PH) 是一个普遍的全球性疾病.
- 在临床PH环境中,关于前血栓状态指标的数据有限.
研究的目的:
- 在PH患者中确定先血栓状态指标.
- 分析PH严重程度的指标差异.
- 为管理高血压血栓性疾病提供实验室基础.
主要方法:
- 对PH患者 (1-3级) 和健康志愿者 (对照组) 的回顾性分析.
- 炎症,血液学和凝血指标的比较.
- 多变量逻辑回归和ROC曲线分析.
主要成果:
- 在PH等级和对照组之间,hs-CRP,TM,Hct,ESR,CD62P,FIB,PLT,APTT,PT和TT的显著差异.
- hs-CRP,TM,Hct,ESR,CD62P,APTT,PT和TT (高表达) 和PLT,FIB (低表达) 被确定为PH进展的危险因素.
- 在ROC分析中,hs-CRP,TM,ESR,CD62P,APTT,PT,TT和FIB的预测值是理想的.
结论:
- 血栓前状态指标 (hs-CRP,TM,Hct,ESR,CD62P,PLT,APTT,PT,TT,FIB) 在PH中显示出不同的模式.
- 特定的表达水平 (高hs-CRP,TM,Hct,ESR,CD62P,FIB;低PLT,APTT,PT,TT) 对PH发生,进展和血栓形成至关重要.
- 基于这些指标的有针对性的干预措施可以管理PH进展并降低血栓形成风险.
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