血清铁的波动将铁亡过程与急性胰腺炎的死亡率和预后联系在一起
Yueling Deng1, Tao Jiang1, Jinhao Li2
1Health Management Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
iScience
|September 20, 2023
概括
细胞死亡过程 - - 铁亡与急性胰腺炎 (AP) 的死亡率有关. 血清铁和乳酸盐等关键因素会影响患者的结果,这表明铁灭症.
科学领域:
- 生物医学科学 生物医学科学
- 细胞生物学 细胞生物学
- 医学研究 医学研究
背景情况:
- 最近,慢性胰腺炎中证实了受调节的细胞死亡,即铁亡.
- 它在急性胰腺炎 (AP),特别是严重病例中的作用仍未得到研究.
研究的目的:
- 调查铁病在急性胰腺炎患者的死亡率和预后中的作用.
- 为了确定影响AP患者结果的与铁亡相关的因素.
主要方法:
- 873名AP患者 (MIMIC-III培训组) 和218名AP患者 (外部验证组) 的回顾性分析.
- 对1188名NAFLD患者的分析 (MIMIC-III内部验证集).
- 回归分析,名图,AUC和DCA,以评估死亡率和铁死因子 (血清铁,ALP,乳酸盐) 之间的相关性.
主要成果:
- 血清铁,铁结合能力 (IBC),性酸酶 (ALP) 和乳酸被确定为AP死亡率和预后的独立因素 (p < 0.05).
- 这些因素在名图,AUC和DCA分析中显示出显著的预测价值.
结论:
- 铁亡和随后的编程细胞死亡在急性胰腺炎的临床结果中起着重要作用.
- 已确定与铁亡相关的因素为AP管理中的临床干预提供了潜在的目标.
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