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使用综合生物信息学分析识别Sjögren综合征和动脉样硬化之间的共享机制和共同生物标志物

Xiaoyi Qi^1,2, Qianwen Huang¹, Shijia Wang¹

¹Departments of Cardiology, Peking University Shenzhen Hospital, Shenzhen, China.

Frontiers in medicine

|September 20, 2023

概括

这项研究确定了四个关键基因 (CTSS,IRF8,CYBB,PTPRC) 参与了Sjögren综合征 (SS) 和动脉样硬化 (AS) 的共享致病性. 这些发现为这些自身免疫和心血管疾病提供了潜在的诊断和治疗点.

科学领域:

免疫学免疫学免疫学
心血管生物学心血管生物学
生物信息学是一种生物信息学.

背景情况:

肖格伦综合征 (SS) 是一种具有多种症状的慢性自身免疫性疾病.
SS被认为是动脉样硬化 (AS) 的独立危险因素.
关联SS和AS的确切病理生理机制尚不清楚.

研究的目的:

调查SS和AS病理生理学的共同基因和通路.
为了确定诊断和治疗这两种疾病的潜在分子标.

主要方法:

来自SS和AS患者队伍的微阵列数据的生物信息分析.
鉴定差异表达基因 (DEGs) 和常见的DEGs.
蛋白质与蛋白质相互作用网络的构建和枢纽基因的识别.
使用外部数据集和基因组丰富分析 (GSEA) 的验证.

主要成果:

确定了8个枢纽基因,其中4个 (CTSS,IRF8,CYBB,PTPRC) 已被证实是SS和AS之间的关键交叉基因.
免疫透分析表明,淋巴细胞和巨细胞在两种疾病的发病过程中都起着重要的作用.
GSEA揭示了代谢和自身免疫性疾病相关途径中共享基因的丰富.

结论:

这项研究是第一个探索SS和AS之间的共同致病机制的研究.
确定了CTSS,CYBB,IRF8和PTPRC作为关键基因,与SS和AS的病原发生有关.
这些已识别的枢纽基因及其免疫细胞相关性代表了未来诊断和治疗策略的有希望的目标.

关键词:

在 GEO 数据库中.斯约格伦综合征是什么意思动脉样硬化动脉样硬化生物信息学是一种生物信息学.免疫透免疫透是什么?

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