雷米马佐拉姆和严重不良事件:一个范围审查
Sander Kempenaers1, Tom G Hansen, Marc Van de Velde
1From the Department of Anaesthesiology, University Hospitals Leuven, Leuven, Belgium (SK), Department of Anaesthesia and Intensive Care, Akershus University Hospital, Lorenskog (TGH), Faculty of Medicine, Institute of Clinical Medicine, Oslo University, Oslo, Norway (TGH), Department of Cardiovascular Sciences, KU Leuven (MVdV) and Department of Anaesthesiology, University Hospitals Leuven, Leuven, Belgium (MVdV).
雷米马佐拉姆提供了麻醉和镇静剂的好处,但具有过敏反应,延迟出现和重新镇静的风险. 对这些严重不良事件的进一步调查对于安全的临床使用至关重要.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
- 临床安全 临床安全
背景情况:
- 雷米马佐拉姆将米达佐拉姆的药理动力学与雷米芬坦尼尔的药理动力学结合起来.
- 新出现的病例报告强调了严重的不良事件:过敏反应,延迟出现和重新镇静.
- 这些事件需要进行彻底的调查,以确保安全的临床应用.
研究的目的:
- 为了调查与雷米马佐拉姆药物管理相关的严重不良事件.
- 分析过敏反应的发生率和潜在原因,延迟出现和重新镇静.
主要方法:
- 系统地搜索PubMed和EMBASE的文献,寻找关于雷米马佐拉姆严重不良反应的研究.
- 包括病例报告和涉及雷米马佐拉姆用于镇静或麻醉的试验.
- 分析报告的事件,包括低血压,延迟出现,过敏反应和重新镇静.
主要成果:
- 分析了36个病例报告和73个试验 (6740名患者).
- 低血压 (911例) 出现的频率低于其他麻醉剂.
- 报告了延迟出现 (68例),过敏反应 (10例) 和复静 (8例) 的情况.
- 延迟出现的危险因素包括较高的BMI,年龄较大和低专蛋白.
- 过敏反应可能涉及辅助剂或与药物相关的反应;与flumazenil逆转相关的再镇静.
结论:
- 雷米马佐拉姆表明潜在的低血压的发生率较低.
- 延迟出现是多因素的,受CES1代谢,患者因素和抑制剂的影响.
- 过敏反应和复静需要仔细考虑和管理策略.
- 在出现延迟的患者中,应谨慎使用flumazenil逆转.
更多相关视频
07:02A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
Published on: February 11, 2019
05:59Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System
Published on: October 20, 2023
相关概念视频
Sedatives and Hypnotics Drugs: Miscellaneous Agents
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Pharmacovigilance
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
REM Sleep Behavior Disorder
RBD is significantly associated with...
Management of Insomnia
Sedatives and Hypnotics: Overview
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
Antiepileptic Drugs: Potassium Channel Activators
Ezogabine has gained approval as an adjunctive treatment...
