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The upper respiratory tract plays a vital role in the respiratory system, comprising several structures that facilitate air intake and prepare air for the lungs. It also serves as the first line of defense against pathogens and particles. This tract includes the nose and nasal cavity, the oral cavity, the paranasal sinuses, and the pharynx, each with specific functions and features.
Nose and nasal cavity
The nose and nasal cavity represent the main external openings of the respiratory tract....
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Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
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在鼻恶性瘤中不同组织学类型中的失败模式:使复杂变得简单

Qian Liu1, Meng Sun1, Zekun Wang1

  • 1Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
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腺状囊性癌 (ACC) 显示出局部复发和远程转移的中度风险. 其他鼻恶性瘤,如状细胞癌 (SCC) 和粘膜黑色素瘤 (MM),对这些失败具有更高的风险.

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科学领域:

  • 在瘤学瘤学.
  • 头部和部手术 头部和部手术
  • 病理学 病理学 病理学

背景情况:

  • 鼻恶性瘤 (SNMs) 包含一组不同的罕见癌症.
  • 了解失败模式对于优化治疗策略至关重要.
  • 组织学亚型显著影响SNMs的预后和治疗结果.

研究的目的:

  • 为了调查和比较不同类型的鼻恶性瘤的组织学亚型的失败模式.
  • 确定具有较高局部复发和远程转移风险的特定亚型.

主要方法:

  • 从一个学术大学医院回顾分析患者数据.
  • 包括1999年至2019年期间被诊断患有SNMs的897名患者.
  • 评估失败模式,包括局部复发 (LR) 和远程转移 (DM),按组织学亚型分层.

主要成果:

  • 腺状囊性癌 (ACC) 显示了LR和DM的中等风险.
  • 状细胞癌 (SCC),腺癌 (AC),软组织肉瘤 (STS) 和粘膜黑色素瘤 (MM) 与LR的高风险相关.
  • 神经内分泌癌 (NEC),STS和MM被确定为DM的高风险组.

结论:

  • 对于局部和远程故障,ACC具有中间风险.
  • SCC,AC,STS和MM与局部复发的风险增加有关.
  • NEC,STS和MM具有远程转移的高风险,需要密切监测和量身定制的管理.