与SARS-CoV-2感染或COVID-19疫苗相关的皮肤肌肉炎
Maximiliano Diaz-Menindez1, Megan M Sullivan1, Benjamin Wang2
1Mayo Clinic, Scottsdale, Arizona.
Arthritis care & research
|September 20, 2023
概括
在COVID-19感染或接种疫苗后,在12.2%的患者中观察到皮肤肌肉炎 (DM) 症状,包括新病例和复发. 该研究发现了这些事件与DM发病之间的时间联系,建议进一步研究底层机制.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 在SARS-CoV-2感染和COVID-19疫苗接种后,新发性和复发性皮肤肌肉炎 (DM) 已有事报告.
- 了解这些事件的特征和频率对于患者管理和公共卫生意识至关重要.
研究的目的:
- 描述COVID-19感染或接种疫苗后出现新发病或复发性皮肤肌炎 (DM) 的患者队列.
- 在这个队列中调查DM的时间关系和临床特征.
主要方法:
- 在2020年3月至2022年10月期间,对98名为DM治疗的患者进行了回顾性审查.
- 在SARS-CoV-2感染或COVID-19疫苗接种后,对新发病或复发的DM患者病历的评估.
- 数据收集包括症状发作,疫苗接种细节和疾病特征.
主要成果:
- 12.2% (98人中12人) 的患者在感染或接种疫苗后出现了新发病或复发的DM.
- 症状发作平均发生在感染后3.2天和接种疫苗后5.75天.
- 75%的受影响患者具有肌肉炎特异性抗体;没有特定的疫苗主要与DM相关.
结论:
- 在12.2%的评估患者中,COVID-19感染/接种疫苗和皮肤肌炎发作或复发之间存在显著的时间关系.
- 需要进一步的研究来阐明潜在的病理生理学,将COVID-19和皮肤肌炎联系起来.
相关概念视频
Myocarditis I: Introduction
9
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
9
Myocarditis II: Clinical Features and Diagnostic Tests
12
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
12
Myocarditis III: Medical Management
7
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
7
Skin Diseases and Disorders
3.9K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
3.9K
Autoimmune Disorders
492
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
492
Reticular Dermis
2.6K
The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
2.6K


