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化疗剂对非小细胞肺癌体内免疫检查点表达的作用

Yu Zhao^1,2,3, Zhe Wang^1,2,3, Xiuhuan Shi^1,2,3

¹Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China.

Technology in cancer research & treatment

|September 20, 2023

概括

化疗药物改变非小细胞肺癌细胞中的免疫检查点联结体表达,影响免疫治疗的有效性. 了解这些变化是优化组合治疗策略的关键.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
药理学药理学是指药理学的学科.

背景情况:

免疫检查点 (ICP) 对瘤细胞的表达会影响免疫治疗的结果.
瘤细胞上的ICP连接体可以抑制免疫细胞的活动,促进瘤免疫逃生.

研究的目的:

研究各种化疗药物如何影响不同非小细胞肺癌 (NSCLC) 亚型中的ICP表达.
为开发改进的化疗方案与ICP阻断相结合提供理由.

主要方法:

在NSCLC细胞系 (状癌H1703,腺癌A549,大细胞癌H460) 接受了72小时的第一线化疗剂 (cisplatin,carboplatin,paclitaxel,gemcitabine,vinorelbine,pemetrexed) 治疗.
使用流细胞计分析了ICP表达的变化.

主要成果:

西斯普拉丁,碳普拉丁和帕克利塔塞尔在A549和H460细胞中增加了编程细胞死亡配体1 (PD-L1) 和PD-L2.
在所有测试的NSCLC细胞系中,维诺雷尔宾和佩姆特雷克塞德增加了PD-L1和PD-L2.
几种药物在细胞系依赖的方式上调了其他ICP配体,如 galectin-9,HMGB1,MHC-II,galectin-3,α-synuclein,FGL1,CD155,CD112和MHC-I.

结论:

化疗剂根据病理类型在NSCLC细胞中差异调节ICP配体表达.
这些对ICP连接体的多种影响可能会影响联合免疫治疗的疗效.
这些发现支持优化联合化疗和免疫疗法方案.

关键词:

在NSCLCLC中,我们可以看到.化学疗法化疗化疗组合疗法治疗组合治疗.免疫检查点是一个检查点.免疫疗法免疫疗法

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