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克洛尼丁在脊髓麻醉期间对心率波动的影响:随机临床试验
Hermes Melo Teixeira Batista1,2, Solange Kelly Lima Araújo2, Galba Matos Cardoso de Alencar Júnior2
1Centro Universitário Faculdade de Medicina do ABC (FMABC), Brazil.
Anaesthesiology intensive therapy
|September 20, 2023
概括
作为脊髓麻醉的辅助剂,克隆丁在运动功能恢复后,没有改变自主恢复,通过心率变化 (HRV) 测量. 这项研究发现,在接受布皮瓦卡因与克洛尼丁或不接受布皮瓦卡因的组之间,HRV参数没有显著差异.
科学领域:
- 麻醉学 麻醉学
- 自主神经系统研究 自主神经系统研究
- 心脏病学 心脏病学
背景情况:
- 脊髓麻醉涉及感觉,运动和自主阻塞,但恢复通常仅由运动功能来评估.
- 自主阻塞与大多数脊柱麻醉并发症有关.
- 心率变化 (HRV) 提供了自主神经系统活动的间接测量,并可能有价值的评估恢复.
研究的目的:
- 在接受脊髓麻醉的患者中,在运动功能的恢复点使用HRV来评估自主功能.
- 为了确定克洛尼丁作为布皮瓦卡因的辅助剂是否会影响脊髓麻醉后的自主恢复.
主要方法:
- 一个随机的双盲临床试验,涉及64名接受脊髓麻醉的患者 (ASA I-II).
- 患者被分为两组:一组接受布皮瓦卡因与克洛尼丁,另一组仅接受布皮瓦卡因.
- 心率变化 (HRV) 在休息时和运动功能恢复时使用Polar V800®监视器和Kubios 3.0®软件进行评估.
主要成果:
- 在LF/HF比率,SD2/SD1,DFAα1,DFAα2或D2指数中,在组之间或时间点之间没有发现显著差异.
- 克洛尼丁组在近似 (ApEn) (P=0.0124) 中显示出显著的差异.
结论:
- 作为脊柱麻醉的辅助剂,克隆丁没有显著改变交感或运动阻塞的持续时间.
- 通过HRV评估的自主恢复在使用克洛尼丁时在运动功能恢复时没有显著差异.
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