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Updated: Jun 15, 2026

Assaying β-amyloid Toxicity using a Transgenic C. elegans Model
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在C.中通过细胞外蛋白酶去除细胞外人类粉样蛋白β聚合物. 伊莱根斯 (elegans) 是一个词

Elisabeth Jongsma1, Anita Goyala1, José Maria Mateos2

  • 1Laboratory of Extracellular Matrix Regeneration, Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zürich, Schwerzenbach, Switzerland.

eLife
|September 20, 2023
PubMed
概括

原蛋白在阿尔茨海默病 (AD) 中影响粉样β (Aβ) 斑块的形成. 发现一种金属蛋白酶ADM-2对于清除这些细胞外Aβ聚合物在体内至关重要.

关键词:
在ADAM9中,ADAM9是ADAM9的前身.阿尔茨海默氏症的疾病是阿尔茨海默氏症.这里是C. elegans.时间表 (TIMP)聚合方式 聚合方式 聚合方式氨基βββββββββββββββββββββββββ细胞生物学 细胞生物学原蛋白是一种原蛋白.神经科学 神经科学

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Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...