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解密得分预测前列腺切除术后前列腺特异性抗原的持续性.

Patrick-Julien Treacy1,2,3, Ugo G Falagario4,5, François Magniez4

  • 1Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, USA - pj.treacy@live.fr.

Minerva urology and nephrology
|September 20, 2023
PubMed
概括
此摘要是机器生成的。

手术后持续的前列腺特异性抗原 (PSA) 表示预后更差. 这项研究确定了独特的基因组特征,并证实了解密分数作为预测因素,建议进一步对高风险患者进行早期治疗强化成像.

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科学领域:

  • 泌尿器科 泌尿器科 泌尿器科 泌尿器科
  • 基因组学就是基因组学.
  • 在瘤学瘤学.

背景情况:

  • 在急性前列腺切除术 (RP) 后,持续性前列腺特异性抗原 (PSA) 与较差的结果有关.
  • 评估持续PSA (pPSA) 患者的基因组风险对于预后至关重要.

研究的目的:

  • 用mRNA表达和经过验证的基因组风险分类器来评估pPSA患者的基因组风险.
  • 在特定的患者亚群中识别pPSA和差异性基因表达的预测因子.

主要方法:

  • 对564名接受RP的患者进行了回顾性单中心研究,分析了基于连续PSA>0.1 ng/mL的PPSA.
  • 使用解密测试并对ppsa预测器进行多变量分析.
  • 进行了基因组差异表达分析,比较局部,器官受限,负边缘亚群中的pPSA和没有pPSA的患者.

主要成果:

  • 在564名患者中,有61人患有pPSA,在这个群体中,手术前PSA和PSA密度较高.
  • 解密得分 (OR=5.64) 和手术前PSA (OR=1.06) 在多变量分析中是pPSA的显著预测指标.
  • 两个基因SERPINB11和PDE11A在ppsa亚群中显著上调 (2.5倍变化).

结论:

  • 患有ppsa的患者表现出明显的基因组特征和更差的预后.
  • 基因组分析,包括解密分数,有助于识别高风险患者.
  • 建议在pPSA患者的早期治疗选择中进行进一步的成像研究.