已故脏捐赠者的暴露后的移植结果,以对比中等
Kinita A Chotkan1,2, Luuk B Hilbrands3, Hein Putter4
1Department of Surgery, Leiden University Medical Center, Leiden, the Netherlands.
Transplantation
|September 20, 2023
概括
在已故的器官捐赠者中使用对比剂不会对移植结果产生负面影响. 这项研究在接受者中没有发现延迟移植功能或长期移植存活的风险增加,其捐赠者接受了对比剂.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 移植医学 移植医学
- 放射学 放射学是一门学科.
背景情况:
- 对比介质的使用与急性损伤有关.
- 捐助者对比介质暴露对移植结果的影响仍未得到充分研究.
研究的目的:
- 调查已故器官捐献者的对比剂暴露与脏移植结果之间的关联.
- 评估对延迟移植功能,移植存活率和长期功能的影响.
主要方法:
- 在荷兰,对已故脏捐赠者 (2011-2021) 和接受者的回顾性分析.
- 多变量分析评估了对比介质暴露与延迟的移植功能和移植存活的联系.
- 线性混合模型评估了移植后估计的膜过率 (eGFR) 的差异.
主要成果:
- 24%的捐赠者接受了对比剂;在脑死亡 (DBD) 后捐赠或循环死亡 (DCD) 后捐赠的捐赠者中,对延迟的移植功能没有显著影响.
- 对比介质的使用与增加DGF风险 (OR 1.06) 或死亡审查的移植失败 (HR 1.01) 并没有显著关联.
- 在移植后1-6年接受者中没有观察到平均eGFR的显著差异.
结论:
- 对比介质在DBD和DCD捐赠者中使用,不会对早期或长期移植功能产生不利影响.
- 研究结果表明,对照剂暴露在供体对照剂中对于移植是安全的.
- 让移植专业人员对潜在器官捐赠者的对比剂使用感到放心.
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