一个基于人口的评分系统,以评估个体风险因素对血管健康的影响
Vanessa Gagliano1, David Gehrig2, Rosaria Del Giorno2,3
1Department of Internal Medicine, Clinical Research Unit, Regional Hospital of Bellinzona and Valli, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.
Aging and disease
|September 20, 2023
概括
通过脉冲波速度 (PWV) 和增强指数 (AI) 测量的动脉硬性受到心血管风险因素的影响. 这项研究提供了参考值和风险评分,以评估它们对血管衰老的影响.
科学领域:
- 心血管健康 心血管健康
- 血管衰老 血管衰老
- 动脉硬性的生物标志物
背景情况:
- 动脉硬是血管健康的关键指标,受衰老和心血管风险因素的影响.
- 脉冲波速度 (PWV) 和增强指数 (AI) 是评估动脉硬性的既定措施.
- 了解个体风险因素对血管衰老的影响对于预防策略至关重要.
研究的目的:
- 评估个体心血管风险因素对血管健康的影响.
- 评估在没有可修改心血管风险因素的成年人中PWV和AI的分布.
- 分析风险因素在加快血管衰老中的作用,使用名图和风险评分.
主要方法:
- 瑞士一项以人口为基础的研究 (2017-2018) 的二次分析,共有1097名参与者.
- 分类为具有或没有特定心血管风险因素的组 (吸烟,糖尿病,心血管疾病,CKD,高胆固醇血症,高血压,代谢综合征).
- 评估PWV和AI使用度和振荡计设备;物流回归和nomogram开发风险分层.
主要成果:
- 高血压,糖尿病和肥胖与明显更高的PWV值相关 (p < 0.001).
- 单变量分析确定了糖尿病,心血管疾病,高胆固醇血症和高血压作为较高PWV的预测因素.
- 多变量分析强调心血管疾病,抗高脂血症治疗,高血压和增加的BMI作为动脉硬的显著预测因素.
结论:
- 该研究确定了没有主要心血管风险因素的个体中PWV和AI的参考值.
- 开发的诺米图提供了一个风险分数,用于分层各个风险因素对血管健康的影响.
- 高血压和糖尿病是增加动脉硬性和潜在加速血管衰老的重要因素.
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