内脏和皮下腹部脂肪预测了10,001名中年人的大脑体积损失
Cyrus A Raji1, Somayeh Meysami2,3, Sam Hashemi4,5
1Mallinckrodt Institute of Radiology, Neuroradiology Division, Washington University in St. Louis, MO, USA.
Aging and disease
|September 20, 2023
概括
过多的腹部脂肪,包括内脏和皮下脂肪,与大脑体积的减少以及灰色和白色物质损失的风险增加有关. 这突出了大脑健康的潜在可修改因素.
科学领域:
- 神经成像是一种神经成像.
- 放射学 放射学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 腹部肥胖是一个日益关注的问题,对认知功能的潜在影响.
- 新出现的证据表明,身体脂肪分布和大脑健康之间存在联系.
研究的目的:
- 为了研究腹部脂肪储存 (内脏和皮下) 与大脑体积之间的关联.
- 为了确定与高腹部脂肪水平相关的大脑体积损失的风险.
主要方法:
- 在10.001名健康参与者中利用1.5TMRI进行全身成像.
- 使用深度学习 (FastSurfer) 来对96个大脑区域进行细分.
- 应用回归分析,将腹部脂肪与大脑体积相关联,控制年龄和性别.
主要成果:
- 内脏腹部脂肪显著预测了多个大脑区域的较低体积,包括灰质,白质,海马体,额叶皮层和叶片.
- 与男性相比,女性的脑体积较小,与内脏脂肪增加有关.
- 在所有年龄组中,较高的内脏脂肪增加了总灰质和白质体积较低的风险.
结论:
- 内脏和皮下腹部脂肪都与大脑体积的减少有关.
- 腹部脂肪可能代表维护大脑健康的新型,可修改的风险因素.
- 研究结果强调了管理腹部脂肪对神经健康的重要性.
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