氨酸和氨酸之间的穿:对癌症免疫营养的影响
R Sindhu1, M Supreeth2, Shashanka K Prasad3
1Department of Microbiology, JSS-Academy of Higher Education and Research, Mysuru, 570015, Karnataka, India. sindhur@jssuni.edu.in.
Amino acids
|September 20, 2023
概括
氨基酸补充剂可以支持癌症免疫力,但L-lysine可能会阻碍L-arginine.
科学领域:
- 营养科学 营养科学
- 癌症生物学 癌症生物学
- 免疫学 免疫学 免疫学
背景情况:
- 氨基酸对细胞生存至关重要,可以为癌细胞提供燃料.
- 氨基酸限制是一种癌症治疗方法,但缺乏氨基酸会损害免疫功能.
- 氨基酸充当"免疫营养素",支持免疫功能并阻止癌症的进展.
研究的目的:
- 审查L-氨酸作为癌症免疫营养素的作用.
- 为了研究L-lysine对L-arginine影响的干扰.
- 探索氨酸-氨酸对抗作用对癌症免疫和治疗的影响.
主要方法:
- 文献综述侧重于L-氨酸,L-氨酸和氧化 (NO) 途径.
- 分析氨酸-氨酸对抗性及其对免疫反应的影响.
- 讨论潜在的治疗策略和未来的研究方向.
主要成果:
- 氨酸是通过氧化 (NO) 生成免疫反应的关键调节剂.
- 高度的L-lysine可以抑制L-arginine的吸收和NO的产生.
- 氨酸-氨酸对抗性可能会损害L-氨酸的免疫营养益处.
结论:
- 与L-arginine的L-lysine干扰可能会降低其抗癌和免疫营养作用.
- 监测氨酸水平对于优化基于L-氨酸的免疫营养疗法至关重要.
- 需要进一步的研究来验证在癌症治疗中对氨酸-氨酸对抗性假设.
相关概念视频
Tumor Immunotherapy
554
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
554
Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
Cancer Vaccines
399
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
399
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K


