使用超声波多普勒对晚期新生儿败血症系统循环的评估及其临床相关性:一项观察性研究
Pari Singh1, Arjun Verma2, Nandini Malshe1
1Department of Neonatology, Bharati Vidyapeeth Deemed University Medical College, Pune, Maharashtra, 411043, India.
Journal of ultrasound
|September 20, 2023
概括
晚期新生儿败血症 (LONS) 改变了大脑,肠道和脏的血液流动. 这些多普勒测速变化可能会增加严重并发症的风险,如心室内出血,死角性肠球炎和急性损伤.
科学领域:
- 新生儿医学 新生儿医学
- 儿童心脏病学 儿童心脏病学
- 医疗成像医学成像
背景情况:
- 晚期新生儿败血症 (LONS) 是新生儿的一个危急病.
- 早期发现和了解LONS相关并发症对于改善结果至关重要.
- 多普勒测速法提供了一种非侵入性的方法来评估器官 perfusion.
研究的目的:
- 测量多普勒测速参数在前脑动脉 (ACA),上半导体动脉 (SMA),和脏动脉 (RA) 的新生儿与LONS.
- 为了将这些血液动力学变化与临床疾病相关联,例如静脉内出血 (IVH),瘤性肠球炎 (NEC) 和急性损伤 (AKI).
主要方法:
- 在第三级新生儿重症监护病房进行了前性观察性研究.
- 招募了20名LONS新生儿和20名妊娠年龄匹配的对照.
- 连续超声波与多普勒测速测量ACA,SMA和RA在第1,3天和第7天进行.
主要成果:
- 与对照人群相比,患有LONS的新生儿在ACA,SMA和RA中表现出明显更高的峰值缩速度,电阻指数和脉动性指数.
- 在LONS新生儿的ACA和RA中,终端透缩速度显著降低.
- 在LONS组中观察到IVH (45%),NEC (50%) 和AKI (10%) 的高发病率.
结论:
- 晚期发病的新生儿败血症与大脑,和脏血流的显著改变有关.
- 在LONS中异常的血管阻力和血液流速测可能使新生儿易患严重并发症.
- 这些发现突显了多普勒超声波在监测器官输液和预测败血症新生儿的结果方面的潜力.
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