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Updated: Jul 15, 2026

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在CeTeG/NOA-09试验中未检测到的伪进展:从进展后生存率和MRI分析中得到的提示

Thomas Zeyen1, Daniel Paech2, Johannes Weller1

  • 1Division of Clinical Neurooncology, Department of Neurology, University Hospital Bonn, Bonn, Germany.

Journal of neuro-oncology
|September 20, 2023
PubMed
概括

洛穆斯丁/特莫索洛米德 (CCNU/TMZ) 在质母细胞瘤患者的整体存活率有所改善. 一个用CCNU/TMZ治疗的小组经历了短暂的无进展生存,但长期的后进展生存,表明伪进展.

关键词:
质母细胞瘤 (glioblastoma) 是一个通过MGMT促进剂甲基化.这就是为什么MRI是MRI.一个进步的进步.伪进步是一种伪进步.

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Irradiation of a spin-active nucleus causes an increase or decrease in the signal intensity of neighboring nuclei that are not necessarily chemically bonded or involved in J-coupling. This phenomenon, called the nuclear Overhauser enhancement (NOE), results from through-space interactions between the nuclear spins. The NOE effect decreases with increasing internuclear distance and is generally not observed beyond 4 angstroms. In NOE, dipole-dipole interactions between neighboring spin-active...
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Insensitive Nuclei Enhanced by Polarization Transfer (INEPT) is an advanced Nuclear Magnetic Resonance (NMR) technique specifically designed to detect and enhance the signals of low-abundance nuclei, such as carbon-13 and nitrogen-15, in small molecules. The fundamental principle behind INEPT is the transfer of polarization from a more abundant and highly polarizable nucleus, typically hydrogen-1, to the low-abundance nucleus of interest. This process effectively boosts the NMR signal of the...
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Description
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
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