产前暴露于不持久的环境化学物质和产后抑郁症
Melanie H Jacobson1, Ghassan B Hamra2, Catherine Monk3,4
1Department of Pediatrics, Division of Environmental Pediatrics, NYU Grossman School of Medicine, New York, New York.
JAMA psychiatry
|September 20, 2023
概括
产前接触某些酸盐可能与产后抑郁症 (PPD) 有关. 这些常见的环境化学物质可能是预防策略的目标. 需要进一步的研究来证实这些发现.
科学领域:
- 环境健康 环境健康
- 生殖健康 生殖健康
- 心理健康 心理健康
背景情况:
- 产后抑郁症 (PPD) 影响着相当一部分生育期的个体,对修改风险因素的选择有限.
- 环境化学物质的暴露,包括,酸盐和类,是潜在的可修改物质,并与PPD有关.
研究的目的:
- 为了调查产前暴露于,酸盐,类和三甲与PPD症状之间的关联.
主要方法:
- 一项前性队列研究,利用来自美国5个出生队列 (2006-2020) 的汇总数据.
- 在怀孕期间测量了醇,甲酸盐代谢产物, parabens 和 triclocarban 的尿度.
- 在产后使用标准化抑郁查工具评估PPD症状.
主要成果:
- 几乎所有参与者都有可检测到的甲酸盐代谢产物和类的水平.
- 较高分子量 (HMW) 甲酸盐显示了与增加PPD几率的潜在关联.
- 低分子量 (LMW) 甲酸盐显示出与较高的抑郁症得分相关的趋势.
结论:
- 酸盐是常见的环境化学物质,可能与PPD有关.
- 这些发现表明,酸盐可能是预防PPD的可修改目标.
- 需要进一步的研究来验证这些协会,并为干预措施提供信息.
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