基于网络的灰色物质传播在精神病的不同阶段发生变化
Sidhant Chopra1,2,3, Ashlea Segal1,2, Stuart Oldham1,2
1Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Clayton, Victoria, Australia.
JAMA psychiatry
|September 20, 2023
概括
大脑网络架构影响灰质减少精神疾病. 前海马是病理传播的关键中心,随着疾病的进展,变化从后部转移到前额叶皮层.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 脑部成像 脑部成像
背景情况:
- 精神病的特点是灰色质量减少,随着时间的推移,这种情况可能会恶化.
- 驱动这些灰色物质变化的空间模式的潜在机制仍然不清楚.
- 大脑网络架构可能在限制这些变化方面发挥作用.
研究的目的:
- 为了研究大脑网络架构如何影响精神疾病中的灰质变化.
- 确定灰色物质损失在不同疾病阶段传播的潜在中心.
- 为了检查灰色物质体积的横截面和纵向变化.
主要方法:
- 利用了来自四个队伍的534名个体的数据的协调变形模型和网络扩散模型.
- 包括患有第一发精神病,治疗精神病和确定的精神分裂症的患者,以及健康的对照人群.
- 在3个月和12个月的时间内,使用MRI对未服用抗精神病药物的患者进行了纵向灰色质变化分析.
主要成果:
- 结构网络架构比功能架构更准确地估计了横截面灰色物质体积差异.
- 这些模型成功估计了与疾病和抗精神病药物暴露有关的纵向体积变化.
- 前海马一直被确定为病理传播的假定中心;纵向变化从后部转移到前额叶皮层.
结论:
- 白质纤维充当精神病的病理传播管道,类似于神经退行性疾病.
- 结构连接体从根本上限制了精神病中的大脑变化,无论原因 (疾病或药物).
- 前海马是精神病的早期大脑病理的关键中心,随后扩散到连接的区域.
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