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Obesity

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...

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Assessment of Child Anthropometry in a Large Epidemiologic Study

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替代肥胖标志物和死亡率的替代品

Irfan Khan^1,2,3,4,5, Michael Chong^1,2,3, Ann Le^1,2,3

¹Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada.

JAMA network open

|September 20, 2023

概括

腰比 (WHR) 强烈预测死亡风险,表现优于身体质量指数 (BMI) 和脂肪质量指数 (FMI). 专注于脂肪分布,而不仅仅是质量,对于临床健康建议至关重要.

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科学领域:

流行病学流行病学
公共卫生公共卫生
遗传学是一个遗传学.

背景情况:

体重指数 (BMI) 是一种常见的肥胖度量,但在反映身体组成和脂肪分布方面存在局限性.
关于与最低死亡风险相关的BMI值,目前仍在进行辩论.

研究的目的:

确定腰部至部比率 (WHR),脂肪质量指数 (FMI) 或BMI是否与死亡率有最强烈的关联.
为了比较这些脂肪测量方法在预测死亡风险方面的一致性.

主要方法:

利用英国生物库数据 (N=387,672) 进行观察性和门德尔随机化 (MR) 分析.
包括发现和验证队列与事件死亡分析所有原因和特定原因死亡率.
评估测量和基因确定BMI,FMI和WHR与死亡结果之间的关联.

主要成果:

腰部至部比 (WHR) 显示出与全因死亡率的线性关联,而BMI和FMI显示出J形关联.
基因决定的WHR与全因死亡率的关联比基因决定的BMI更强.
基因决定的WHR与死亡率之间的关联不管测量BMI如何,都是一致的,在男性中更强.

结论:

与BMI和FMI相比,腰部至部比率 (WHR) 是死亡率的优越预测指标,显示出最强和最一致的关联.
临床指南应优先评估脂肪分布 (如WHR),而不是简单的脂肪质量测量 (如BMI).
这些发现强调了脂肪分布在理解死亡风险方面的重要性.