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在ARRIVE指南发布12年后,动物研究尚未达到高标准

Junmin Song¹, Marco Solmi^2,3,4,5,6, Andre F Carvalho⁷

¹Department of Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, USA.

Laboratory animals

|September 20, 2023

概括

尽管有报告准则,但动物研究中的可复制性危机仍然存在. 提高研究质量需要更好的培训,设计,注册和奖励系统,而不仅仅是遵守指南.

科学领域:

* 生物医学研究
*实验室动物科学 *实验室动物科学

背景情况:

* 动物研究结果的可信性受到可再生性危机的威胁.
*动物研究:实体实验报告 (ARRIVE) 准则 (2010年,更新至2020年) 旨在提高透明度,但没有最佳的合规性.
*目前的报告准则可能无法完全解决动物研究中可复制性差的根本原因.

研究的目的:

* 评估报告准则在解决动物研究中的可再生性危机方面的有效性.
* 探索替代性和补充性策略,以提高动物研究的质量和透明度.

主要方法:

*对ARRIVE报告准则的影响和局限性的批判性分析.
* 检查导致研究努力被浪费的因素,包括研究设计不佳和未发表.
*考虑超出报告标准的更广泛的干预措施.

主要成果:

*研究人员和期刊对ARRIVE 2.0的认识和遵守程度仍然不够理想.
*单单报告准则可能不足以改变研究文化或提高可复制性.
*研究设计不佳和未发表是浪费研究资源的重要原因.

结论:

* 提高动物研究的可重复性,需要采用多方面的方法.
*关键干预措施包括改善科学培训,强大的研究设计,强制性注册和修订的奖励系统.
* 转向优先考虑严格的研究实践对于推动科学发现至关重要.

关键词:

时间到达了.动物研究报告 in vivo 实验动物研究动物研究可复制性的可复制性

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