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Updated: Jul 16, 2025

A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform
09:35

A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform

Published on: July 16, 2016

11.2K

在胰腺β细胞中,内质网膜应激会通过ATF4介导的PDE4D表达引发因克雷丁脱敏和β细胞功能障碍

Ji-Hye Lee1,2, Hanguk Ryu1, Hyejin Lee1

  • 1Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of Korea.

American journal of physiology. Endocrinology and metabolism
|September 20, 2023
PubMed
概括

在2型糖尿病 (T2D) 中,胰腺β细胞功能通过PERK-ATF4通路受到内质网膜应激损害. 这项研究表明,ATF4可以调节PDE4D,减少cAMP信号传递,导致β细胞衰竭,这是T2D治疗的可向途径.

关键词:
在ATF4中使用ATF4.压力ERER压力ERER压力这是一个PDE4D.这种药物具有抗素的耐药性.β细胞功能障碍

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