多种癌症早期检测:癌症早期检测的新前沿
Carmen E Guerra1,2,3, Prateek V Sharma4, Brenda S Castillo1,5
1Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA;
Annual review of medicine
|September 20, 2023
概括
新的多种癌症早期检测 (MCED) 试验有望彻底改变癌症查. 本审查审查了它们的性能,潜在的危害以及对临床实践和健康公平的影响.
科学领域:
- 在瘤学瘤学.
- 医学诊断 医学诊断 医学诊断
- 公共卫生 公共卫生
背景情况:
- 早期发现癌症对于改善患者的治疗结果至关重要.
- 许多单一和多种癌症早期检测测试 (MCED) 正在出现.
- 当前的查指南往往不包括这些新的测试.
研究的目的:
- 审查现有的MCED测试的性能特征.
- 批判性地评估与MCED相关的潜在危害.
- 审查正在进行的大规模研究,评估MCEDs的临床影响.
主要方法:
- 关于单种和多种癌症早期检测测试的文献综述.
- 对性能指标的评估:灵敏度,特异性,预测值,准确性.
- 分析潜在风险:错误的结果,过度诊断,过度治疗,心理/经济负担,健康不平等.
主要成果:
- MCED测试显示出不同的表现,其中一些作为现有查的附加品进行商业化.
- 潜在的危害包括错误的阳性/阴性,过度诊断,过度治疗和健康不平等的恶化.
- 目前正在进行大型基于人群的研究,以评估临床效用和实践影响.
结论:
- MCED测试具有显著的潜力,但需要仔细评估好处和危害.
- 了解业绩和风险对于负责任的实施至关重要.
- 目前正在进行的研究将确定MCEDs在改变癌症早期发现和治疗中的作用.
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