血友病无症状成年人心血管风险评分
Ricardo Mesquita Camelo1,2,3, Camila Caram-Deelder3,4, Bruna Pontes Duarte2
1Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG - Brasil.
Arquivos brasileiros de cardiologia
|September 20, 2023
概括
血友病 (PwH) 的巴西老年男性心血管疾病 (CVD) 风险较高. 一半的参与者面临高10年心血管疾病风险,需要改善血脂障碍和血压管理.
科学领域:
- 心脏病学 心脏病学
- 血液学 血液学 血液学
背景情况:
- 巴西血友病 (PwH) 患者的死亡率正在下降.
- 然而,心血管疾病 (CVD) 是PwH中死亡的原因越来越多.
研究的目的:
- 评估PwH的心血管疾病风险得分,使用聚合队列方程风险 (PCER) 计算器.
- 将PCER估计与弗雷明汉风险评分 (FRS) 进行比较.
- 根据心血管疾病风险概述治疗建议.
主要方法:
- 一项横截面研究包括30名40岁以上的男性PwH在巴西雷西菲.
- 排除标准:之前的心血管疾病事件或LDL胆固醇≥5.0 mmol/L.
- 通过采访,医疗记录和血液测试收集的数据;PCER和FRS被计算出来.
主要成果:
- 中位数PCER得分为6.9%,其中50%的PwH被归类为高风险 (≥7.5%).
- 传统心血管疾病风险因素的患病率:高血压 (67%),肥胖 (20%),糖尿病 (24%),高甘油三 (14%),高胆固醇 (47%),低高血压 (23%).
- 对于54%的患者,建议使用静止剂治疗,47%的患者血压控制不良. PCER和FRS显示出良好的一致性 (80%, κ = 0.60).
结论:
- 一半的老年男性PwH表现出高10年心血管疾病风险.
- 需要紧急干预,以管理这种人群中的脂质不良和高血压.
- PCER工具有效地估计了普华永道的心血管疾病风险.
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