原蛋白含量和C-X-C基因化学激素连接体12表达在新发性乳腺层瘤中

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Cindy Juliane da Silva Ferreira¹, Inacelli Queiroz de Souza Caires², Walfrido José Bezerra da Costa Neto³

¹Universidade de Pernambuco, Programa de Pós-Graduação em Biologia Celular e Molecular Aplicada - Recife (PE), Brazil.

Revista da Associacao Medica Brasileira (1992)

|September 20, 2023

概括

低表达C-X-C动机化学因子配体12 (CXCL12) 可能表明乳腺癌的预后更差. 在瘤微环境中的原蛋白含量分析显示了临床应用的潜力,用于预测结果.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
病理学病理学病理学

背景情况:

乳腺癌的进展受到瘤微环境相互作用的影响.
化学因子,如C-X-C动机化学因子联体12 (CXCL12) 和它的受体C-X-C化学因子受体4型 (CXCR4),在癌细胞迁移和存活中发挥作用.
瘤-肌瘤比率,特别是原蛋白含量,越来越多地被认为是预后因素.

研究的目的:

在乳腺癌样本中评估CXCL12和CXCR4的表达.
通过使用原蛋白含量来评估瘤-肌瘤比率.
将这些因素与临床病理学数据和患者存活率相关联.

主要方法:

对女性乳腺癌患者 (1-4阶段) 的回顾性队列研究.
免疫组织化学用于分析树皮细胞特征和化学因子表达 (CXCL12,CXCR4).
戈莫里染色和数字图像分析量化了原蛋白含量,以确定瘤-肌瘤比率.

主要成果:

缺少 stromal CXCL12 表达与更长的无病生存时间相关.
CXCR4表达与较低的无病存活率有关.
与组织学级和血管淋巴细胞侵袭相关的CXCL12表达;与组织学级相关的CXCR4表达.
侵袭性导管癌样本显示较低的原蛋白含量 (39%) 与非新形成性样本 (78%) 相比.

结论:

低CXCL12表达可能与乳腺癌的预后较差有关.
通过数字成像进行原蛋白含量分析,为评估瘤微环境和预测乳腺癌的预后提供了一个有前途的工具.

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