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编程细胞死亡蛋白1是三阴性乳腺癌中新辅助化疗反应的标志物

Maria de Fátima Dias Gaui¹, Luis Claudio Amendola², Danielle Carvalho Quintella³

¹Universidade Federal do Rio de Janeiro, Faculdade de Medicina, Departamento de Clínica Médica - Rio de Janeiro (RJ), Brazil.

Revista da Associacao Medica Brasileira (1992)

|September 20, 2023

概括

化疗增加了瘤透淋巴细胞 (TILs) 和CD8T细胞在三阴性乳腺癌. 治疗前编程细胞死亡蛋白1 (PD-1) 水平可能预测病理反应.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
乳腺癌研究研究乳腺癌研究

背景情况:

三阴性乳腺癌 (TNBC) 通常具有瘤透性淋巴细胞 (TILs),这是关键的免疫细胞,其组成会影响预后.
在TNBC透物中,调节性和效应性淋巴细胞的特定作用仍然不完全理解.
新辅助化疗对TIL组成的影响及其预后意义需要进一步阐明.

研究的目的:

在新辅助化疗前后,量化和描述TNBC中的TIL组成.
评估TILs与新辅助化疗病理反应之间的关联.
评估TIL和TNBC患者的整体存活率之间的关系.

主要方法:

从38名TNBC患者的临床和病理数据的回顾性分析.
使用血素和色素染色方法识别和量化 stromal TILs.
免疫组织化学测定T细胞子集 (CD3,CD4,CD8,FOXP3) 和PD-1表达.

主要成果:

在化疗后观察到 stromal TIL 类别的显著变化,TIL 高的病例增加.
虽然整体TIL水平与病理反应或生存没有显著的相关性,但特定的子集发生了变化.
在化疗后,抗瘤CD8 T细胞增加和抑制FOXP3和PD-1表达细胞减少.
化疗前的PD-1表达与病理反应有显著的关联.

结论:

新辅助化疗明显增加了TILs,包括CD8T细胞和TNBC中的CD8/FOXP3比率.
治疗前PD-1表达成为预测新辅助化疗的TNBC患者病理反应的潜在预后生物标志物.
这些发现突出了化疗的免疫调节作用,并确定PD-1作为一个有前途的预测标记.

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