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使用PARP和MAPK抑制剂的组合治疗克服了晚期黑色素瘤中表型切换驱动的耐药性

Lorenza P Ferretti1, Flurina Böhi1, Deena M Leslie Pedrioli1

  • 1Department of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.

Cancer research
|September 20, 2023
PubMed
概括

PARP 抑制剂 (PARPi) 通过逆转表型切换和诱导细胞死亡,使黑色素瘤对MAPK 抑制剂 (MAPKi) 重新敏感. 这种组合疗法提供了一个有希望的策略,以克服转移性黑色素瘤中获得的耐药性.

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