来自具有可离子化氨基酸或二类极点头的博兰菲菲尔的减少响应性阴离子囊泡
Ana M Bernal-Martínez1, César A Angulo-Pachón1, Francisco Galindo1
1Department of Inorganic and Organic Chemistry, Universitat Jaume I, 12071 Castelló de la Plana, Spain.
Langmuir : the ACS journal of surfaces and colloids
|September 20, 2023
概括
阴离子波拉类形成pH敏感囊泡,可用于潜在的胃肠道输送. 这些自我组装的分子封装了疏水性货物,在特定的环境中释放它们.
科学领域:
- 超分子化学 超分子化学
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
背景情况:
- 玻拉性分子是分子,在性尾巴的两端都有性头部.
- 两性分子自组装成囊泡对于药物递送系统至关重要.
- 控制囊泡形成和货物释放是有针对性的交付应用程序的关键.
研究的目的:
- 为了研究新型阴离子博拉的自我组装到囊泡中.
- 为了描述形成的囊泡的物理化学特性.
- 评估这些囊泡在疏水性货物加载和释放方面的潜力,特别是对于胃肠道输送.
主要方法:
- 合成基于囊胺的博拉胺基与二末端组 (l-valine,l-phenylalanine,l-tryptophan) 的合成.
- 使用烯光和光散射来确定临界聚合度 (CAC) 的聚合研究.
- 通过动态光散射 (DLS) 和传输电子显微镜 (TEM) 进行囊泡表征.
- 在减少条件下进行疏水性货物载荷 (尼罗河红色) 和释放研究.
主要成果:
- 在pH 4下观察到所有测试的二二终结型博拉的囊泡形成.
- 使用光和光散射来确定临界聚合度.
- DLS和TEM证实了囊泡形成,直径在140至500纳米之间.
- 囊泡成功地加载并释放了疏水性载荷,以应对减小刺激.
- 质子和囊泡的形成取决于酸性pH.
结论:
- 在酸性pH值下,二末端的阴性博拉菲菲尔在酸性pH值下自组合成稳定的囊泡.
- 形成的囊泡显示了缩和释放疏水分子的潜力.
- 这些响应pH的囊泡有望成为胃肠道药物递送系统的载体.
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