体中的高能量节奏会引起脉冲性细分收缩
IEEE transactions on bio-medical engineering
|September 20, 2023
概括
高能量节奏有效地刺激了猪的阴收缩,在更高的脉冲幅度下,力量更大. 这种方法对治疗肠道运动障碍而不会造成组织损伤有前途.
科学领域:
- 胃肠病学 胃肠病学
- 生物工程是生物工程.
- 医疗器械 医疗器械
背景情况:
- 损害肠道功能和运动障碍,如术后大肠和慢性肠道伪阻塞,阻碍了消化和营养吸收.
- 肠道运动障碍需要新的治疗策略来恢复有效的胃肠功能.
研究的目的:
- 在猪模型中研究高能量节奏在增强近道关收缩方面的有效性.
- 为了确定诱导局部肠道收缩的最佳节奏参数.
主要方法:
- 系统变化节奏脉冲参数 (脉冲宽度和脉冲振幅) 在体内猪内 (n=7) 中.
- 使用视频映射系统评估诱导的收缩反应,以量化细分收缩和肠直径变化 (菌株).
- 组织学检查节奏组织,以评估任何潜在的组织损伤.
主要成果:
- 高能量节奏成功诱导了细分收缩,在所有测试的脉冲设置中,肠直径减少了6-18%.
- 收缩性响应的大小随着脉冲幅度的增加而显著增加,并且在较小程度上,随着脉冲宽度的增加 (100毫秒到400毫秒).
- 组织学分析显示,即使在最大节奏能量设置 (4-8 mA,400 ms脉冲宽度,5分钟持续时间) 中,也没有明显的组织损伤.
结论:
- 高能量的节奏可靠地诱导小肠中的周期性细分收缩,收缩力与应用的能量成正比.
- 节奏表现出显著的治疗潜力,用于增强肠道运动在患有肠道疾病的患者.
- 这项研究成功地适应了视频映射来评估小肠节奏反应,为临床翻译铺平了道路.
相关概念视频
Muscle Stimulation Frequency
2.3K
The contraction strength of muscles is regulated by motor neurons, which modulate the frequency of action potentials dispatched to the motor units based on the body's requirements. This process of varying the muscle stimulation frequency allows muscles to contract with a force that is precisely tailored to the needs of the moment, whether lifting a feather or a heavy box.
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...
2.3K
Electrophysiology of Normal Cardiac Rhythm
5.7K
The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase...
5.7K
Gastric Motility
813
Gastric motility is the coordinated contraction and relaxation of stomach muscles that convert ingested food into chyme, a semi-liquid substance ready for further digestion in the intestines. The process begins with the vagus nerve inducing the relaxation of the smooth muscles in the fundus and body of the stomach, allowing these regions to expand and accommodate up to approximately 1.5 liters of food and liquid.
Peristaltic Waves and Chyme Formation
Upon food entry, the stomach initiates...
Peristaltic Waves and Chyme Formation
Upon food entry, the stomach initiates...
813
Smooth Muscle Contraction
3.1K
Smooth muscle contraction is a complex process vital for various bodily functions, from maintaining blood vessel tension to facilitating the movement of food through the digestive tract. Unlike striated muscles, smooth muscle contraction begins more slowly and lasts longer.
The onset of contraction is triggered by an increase in calcium ions within the sarcoplasm, similar to the process in striated muscle. However, smooth muscles have a relatively smaller reservoir of the sarcoplasmic...
The onset of contraction is triggered by an increase in calcium ions within the sarcoplasm, similar to the process in striated muscle. However, smooth muscles have a relatively smaller reservoir of the sarcoplasmic...
3.1K
Enteric Nervous System: Regulation of GI Motor Activity
441
The Enteric Nervous System (ENS) plays a pivotal role in regulating gastrointestinal or GI motor activity. This complex network of nerves, deeply embedded within the gut wall, responds to changes in the gut environment and receives input from both the autonomic nervous system and the central nervous system. By doing so, the ENS operates various programs tailored to the body's nutritional status and needs.
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
441
Motor Unit Stimulation
1.6K
When the neuron of a motor unit fires an action potential, it triggers a series of events, leading to a twitch contraction in the muscle fibers. The process of excitation-contraction coupling is crucial in relaying the action potential to the muscle fibers.
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
1.6K


